Compounds > 7-butyl-8-[[4-(3-chlorophenyl)-1-piperazinyl]methyl]-1,3-dimethylpurine-2,6-dione
Page last updated: 2024-11-09

7-butyl-8-[[4-(3-chlorophenyl)-1-piperazinyl]methyl]-1,3-dimethylpurine-2,6-dione

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Cross-References

ID SourceID
PubMed CID666267
CHEMBL ID1444568
CHEBI ID93024

Synonyms (24)

Synonym
smr000035418
MLS000080718 ,
UNM000000844601
MLS002584887
MLS-0004183.0001 ,
MLS-0004183.0002
MLS002699437
AKOS001360565
7-butyl-8-[[4-(3-chlorophenyl)piperazin-1-yl]methyl]-1,3-dimethylpurine-2,6-dione
7-butyl-8-{[4-(3-chlorophenyl)piperazin-1-yl]methyl}-1,3-dimethyl-3,7-dihydro-1h-purine-2,6-dione
STK583726
HMS2413N04
REGID_FOR_CID_666267
cid_666267
7-butyl-8-[[4-(3-chlorophenyl)piperazino]methyl]-1,3-dimethyl-xanthine
bdbm65735
7-butyl-8-[[4-(3-chlorophenyl)piperazin-1-yl]methyl]-1,3-dimethyl-purine-2,6-dione
7-butyl-8-[[4-(3-chlorophenyl)-1-piperazinyl]methyl]-1,3-dimethylpurine-2,6-dione
CHEMBL1444568
SR-01000128109-1
sr-01000128109
CHEBI:93024
Z235449700
Q27164754
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
piperazines
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (35)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Beta-lactamaseEscherichia coli K-12Potency5.62340.044717.8581100.0000AID485341
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency12.58930.177814.390939.8107AID2147
Chain A, CruzipainTrypanosoma cruziPotency7.94330.002014.677939.8107AID1476
ATAD5 protein, partialHomo sapiens (human)Potency22.72650.004110.890331.5287AID504466; AID504467
TDP1 proteinHomo sapiens (human)Potency6.91040.000811.382244.6684AID686978; AID686979
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency15.84890.011212.4002100.0000AID1030
thyroid stimulating hormone receptorHomo sapiens (human)Potency15.84890.001318.074339.8107AID926; AID938
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency19.95260.28189.721235.4813AID2326
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency28.18380.707936.904389.1251AID504333
P53Homo sapiens (human)Potency6.30960.07319.685831.6228AID504706
alpha-galactosidaseHomo sapiens (human)Potency35.48134.466818.391635.4813AID2107
lysosomal alpha-glucosidase preproproteinHomo sapiens (human)Potency70.79460.036619.637650.1187AID1466; AID2242
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency16.36010.00419.984825.9290AID504444
mitogen-activated protein kinase 1Homo sapiens (human)Potency15.84890.039816.784239.8107AID995
ubiquitin carboxyl-terminal hydrolase 2 isoform aHomo sapiens (human)Potency10.00000.65619.452025.1189AID927
gemininHomo sapiens (human)Potency6.51310.004611.374133.4983AID624297
survival motor neuron protein isoform dHomo sapiens (human)Potency15.84890.125912.234435.4813AID1458
lethal factor (plasmid)Bacillus anthracis str. A2012Potency3.16230.020010.786931.6228AID912
lamin isoform A-delta10Homo sapiens (human)Potency2.81840.891312.067628.1838AID1487
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency70.79463.548118.039535.4813AID1466
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)Potency70.79463.548118.039535.4813AID1466
Guanine nucleotide-binding protein GHomo sapiens (human)Potency2.23871.995325.532750.1187AID624287
Disintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)Potency10.00001.584913.004325.1189AID927
TAR DNA-binding protein 43Homo sapiens (human)Potency19.95261.778316.208135.4813AID652104
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
interleukin-8 isoform 1 precursorHomo sapiens (human)IC50 (µMol)25.00000.55074.397718.7700AID2503; AID2504; AID2505
tumor necrosis factorHomo sapiens (human)IC50 (µMol)4.52000.07935.809814.7275AID2483; AID2801
fatty acid synthaseHomo sapiens (human)IC50 (µMol)5.40500.16605.647218.2000AID624326; AID624327
nucleotide-binding oligomerization domain-containing protein 1 isoform 1Homo sapiens (human)IC50 (µMol)4.42580.04313.361918.4900AID2466; AID2789; AID2792; AID2793; AID2798
high affinity choline transporter 1 isoform aHomo sapiens (human)IC50 (µMol)15.13560.00036.210228.8403AID504840
nucleotide-binding oligomerization domain-containing protein 2 isoform 1Homo sapiens (human)IC50 (µMol)1.81001.14607.137219.7000AID2475; AID2799
Retinal dehydrogenase 2Homo sapiens (human)IC50 (µMol)100.00004.50004.50004.5000AID1199866
Retinal dehydrogenase 1Homo sapiens (human)IC50 (µMol)20.00000.02001.04766.7900AID1199901
Aldehyde dehydrogenase, mitochondrialHomo sapiens (human)IC50 (µMol)100.00000.04003.40799.0000AID1199870
Aldehyde dehydrogenase X, mitochondrialHomo sapiens (human)IC50 (µMol)100.00005.10005.10005.1000AID1199872
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (123)

Processvia Protein(s)Taxonomy
blood vessel developmentRetinal dehydrogenase 2Homo sapiens (human)
kidney developmentRetinal dehydrogenase 2Homo sapiens (human)
liver developmentRetinal dehydrogenase 2Homo sapiens (human)
retinoic acid biosynthetic processRetinal dehydrogenase 2Homo sapiens (human)
heart morphogenesisRetinal dehydrogenase 2Homo sapiens (human)
vitamin A metabolic processRetinal dehydrogenase 2Homo sapiens (human)
midgut developmentRetinal dehydrogenase 2Homo sapiens (human)
cell population proliferationRetinal dehydrogenase 2Homo sapiens (human)
positive regulation of cell population proliferationRetinal dehydrogenase 2Homo sapiens (human)
negative regulation of cell population proliferationRetinal dehydrogenase 2Homo sapiens (human)
determination of bilateral symmetryRetinal dehydrogenase 2Homo sapiens (human)
proximal/distal pattern formationRetinal dehydrogenase 2Homo sapiens (human)
positive regulation of gene expressionRetinal dehydrogenase 2Homo sapiens (human)
neural crest cell developmentRetinal dehydrogenase 2Homo sapiens (human)
morphogenesis of embryonic epitheliumRetinal dehydrogenase 2Homo sapiens (human)
neural tube developmentRetinal dehydrogenase 2Homo sapiens (human)
pituitary gland developmentRetinal dehydrogenase 2Homo sapiens (human)
neuron differentiationRetinal dehydrogenase 2Homo sapiens (human)
lung developmentRetinal dehydrogenase 2Homo sapiens (human)
hindbrain developmentRetinal dehydrogenase 2Homo sapiens (human)
pancreas developmentRetinal dehydrogenase 2Homo sapiens (human)
embryonic camera-type eye developmentRetinal dehydrogenase 2Homo sapiens (human)
response to estradiolRetinal dehydrogenase 2Homo sapiens (human)
response to retinoic acidRetinal dehydrogenase 2Homo sapiens (human)
response to vitamin ARetinal dehydrogenase 2Homo sapiens (human)
response to cytokineRetinal dehydrogenase 2Homo sapiens (human)
embryonic forelimb morphogenesisRetinal dehydrogenase 2Homo sapiens (human)
ureter maturationRetinal dehydrogenase 2Homo sapiens (human)
retinol metabolic processRetinal dehydrogenase 2Homo sapiens (human)
retinoic acid metabolic processRetinal dehydrogenase 2Homo sapiens (human)
retinal metabolic processRetinal dehydrogenase 2Homo sapiens (human)
9-cis-retinoic acid biosynthetic processRetinal dehydrogenase 2Homo sapiens (human)
positive regulation of apoptotic processRetinal dehydrogenase 2Homo sapiens (human)
embryonic digestive tract developmentRetinal dehydrogenase 2Homo sapiens (human)
cardiac muscle tissue developmentRetinal dehydrogenase 2Homo sapiens (human)
protein homotetramerizationRetinal dehydrogenase 2Homo sapiens (human)
face developmentRetinal dehydrogenase 2Homo sapiens (human)
cellular response to retinoic acidRetinal dehydrogenase 2Homo sapiens (human)
retinoic acid receptor signaling pathway involved in somitogenesisRetinal dehydrogenase 2Homo sapiens (human)
regulation of vascular endothelial cell proliferationRetinal dehydrogenase 2Homo sapiens (human)
retinoid metabolic processRetinal dehydrogenase 1Homo sapiens (human)
cellular aldehyde metabolic processRetinal dehydrogenase 1Homo sapiens (human)
gamma-aminobutyric acid biosynthetic processRetinal dehydrogenase 1Homo sapiens (human)
fructosamine catabolic processRetinal dehydrogenase 1Homo sapiens (human)
maintenance of lens transparencyRetinal dehydrogenase 1Homo sapiens (human)
retinol metabolic processRetinal dehydrogenase 1Homo sapiens (human)
cellular detoxification of aldehydeRetinal dehydrogenase 1Homo sapiens (human)
negative regulation of cold-induced thermogenesisRetinal dehydrogenase 1Homo sapiens (human)
carbohydrate metabolic processAldehyde dehydrogenase, mitochondrialHomo sapiens (human)
alcohol metabolic processAldehyde dehydrogenase, mitochondrialHomo sapiens (human)
ethanol catabolic processAldehyde dehydrogenase, mitochondrialHomo sapiens (human)
aldehyde catabolic processAldehyde dehydrogenase, mitochondrialHomo sapiens (human)
regulation of dopamine biosynthetic processAldehyde dehydrogenase, mitochondrialHomo sapiens (human)
regulation of serotonin biosynthetic processAldehyde dehydrogenase, mitochondrialHomo sapiens (human)
carbohydrate metabolic processAldehyde dehydrogenase X, mitochondrialHomo sapiens (human)
ethanol catabolic processAldehyde dehydrogenase X, mitochondrialHomo sapiens (human)
optic cup morphogenesis involved in camera-type eye developmentAldehyde dehydrogenase family 1 member A3Homo sapiens (human)
retinoic acid biosynthetic processAldehyde dehydrogenase family 1 member A3Homo sapiens (human)
apoptotic processAldehyde dehydrogenase family 1 member A3Homo sapiens (human)
locomotory behaviorAldehyde dehydrogenase family 1 member A3Homo sapiens (human)
nucleus accumbens developmentAldehyde dehydrogenase family 1 member A3Homo sapiens (human)
embryonic camera-type eye developmentAldehyde dehydrogenase family 1 member A3Homo sapiens (human)
inner ear morphogenesisAldehyde dehydrogenase family 1 member A3Homo sapiens (human)
retinol metabolic processAldehyde dehydrogenase family 1 member A3Homo sapiens (human)
retinoic acid metabolic processAldehyde dehydrogenase family 1 member A3Homo sapiens (human)
retinal metabolic processAldehyde dehydrogenase family 1 member A3Homo sapiens (human)
positive regulation of apoptotic processAldehyde dehydrogenase family 1 member A3Homo sapiens (human)
embryonic eye morphogenesisAldehyde dehydrogenase family 1 member A3Homo sapiens (human)
neuromuscular process controlling balanceAldehyde dehydrogenase family 1 member A3Homo sapiens (human)
protein homotetramerizationAldehyde dehydrogenase family 1 member A3Homo sapiens (human)
righting reflexAldehyde dehydrogenase family 1 member A3Homo sapiens (human)
olfactory pit developmentAldehyde dehydrogenase family 1 member A3Homo sapiens (human)
face developmentAldehyde dehydrogenase family 1 member A3Homo sapiens (human)
Harderian gland developmentAldehyde dehydrogenase family 1 member A3Homo sapiens (human)
negative regulation of inflammatory response to antigenic stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
renal water homeostasisGuanine nucleotide-binding protein GHomo sapiens (human)
G protein-coupled receptor signaling pathwayGuanine nucleotide-binding protein GHomo sapiens (human)
regulation of insulin secretionGuanine nucleotide-binding protein GHomo sapiens (human)
cellular response to glucagon stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
positive regulation of epidermal growth factor receptor signaling pathwayDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
response to hypoxiaDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
neutrophil mediated immunityDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
germinal center formationDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of leukocyte chemotaxisDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
proteolysisDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
membrane protein ectodomain proteolysisDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
cell adhesionDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
Notch receptor processingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of cell population proliferationDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
response to xenobiotic stimulusDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of T cell chemotaxisDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
protein processingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
signal releaseDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
B cell differentiationDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of cell growthDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of cell migrationDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathwayDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
response to lipopolysaccharideDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of chemokine productionDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of tumor necrosis factor productionDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
regulation of mast cell apoptotic processDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
T cell differentiation in thymusDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
cell adhesion mediated by integrinDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
wound healing, spreading of epidermal cellsDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
amyloid precursor protein catabolic processDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of blood vessel endothelial cell migrationDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of cyclin-dependent protein serine/threonine kinase activityDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of epidermal growth factor-activated receptor activityDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of epidermal growth factor receptor signaling pathwayDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
spleen developmentDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
cell motilityDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
defense response to Gram-positive bacteriumDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
cellular response to high density lipoprotein particle stimulusDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
commissural neuron axon guidanceDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
negative regulation of cold-induced thermogenesisDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of G1/S transition of mitotic cell cycleDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of tumor necrosis factor-mediated signaling pathwayDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of vascular endothelial cell proliferationDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
Notch signaling pathwayDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
negative regulation of protein phosphorylationTAR DNA-binding protein 43Homo sapiens (human)
mRNA processingTAR DNA-binding protein 43Homo sapiens (human)
RNA splicingTAR DNA-binding protein 43Homo sapiens (human)
negative regulation of gene expressionTAR DNA-binding protein 43Homo sapiens (human)
regulation of protein stabilityTAR DNA-binding protein 43Homo sapiens (human)
positive regulation of insulin secretionTAR DNA-binding protein 43Homo sapiens (human)
response to endoplasmic reticulum stressTAR DNA-binding protein 43Homo sapiens (human)
positive regulation of protein import into nucleusTAR DNA-binding protein 43Homo sapiens (human)
regulation of circadian rhythmTAR DNA-binding protein 43Homo sapiens (human)
regulation of apoptotic processTAR DNA-binding protein 43Homo sapiens (human)
negative regulation by host of viral transcriptionTAR DNA-binding protein 43Homo sapiens (human)
rhythmic processTAR DNA-binding protein 43Homo sapiens (human)
regulation of cell cycleTAR DNA-binding protein 43Homo sapiens (human)
3'-UTR-mediated mRNA destabilizationTAR DNA-binding protein 43Homo sapiens (human)
3'-UTR-mediated mRNA stabilizationTAR DNA-binding protein 43Homo sapiens (human)
nuclear inner membrane organizationTAR DNA-binding protein 43Homo sapiens (human)
amyloid fibril formationTAR DNA-binding protein 43Homo sapiens (human)
regulation of gene expressionTAR DNA-binding protein 43Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (44)

Processvia Protein(s)Taxonomy
retinal dehydrogenase activityRetinal dehydrogenase 2Homo sapiens (human)
3-chloroallyl aldehyde dehydrogenase activityRetinal dehydrogenase 2Homo sapiens (human)
retinal bindingRetinal dehydrogenase 2Homo sapiens (human)
aldehyde dehydrogenase (NAD+) activityRetinal dehydrogenase 2Homo sapiens (human)
retinal dehydrogenase activityRetinal dehydrogenase 1Homo sapiens (human)
aldehyde dehydrogenase (NAD+) activityRetinal dehydrogenase 1Homo sapiens (human)
GTPase activator activityRetinal dehydrogenase 1Homo sapiens (human)
androgen bindingRetinal dehydrogenase 1Homo sapiens (human)
protein bindingRetinal dehydrogenase 1Homo sapiens (human)
aminobutyraldehyde dehydrogenase activityRetinal dehydrogenase 1Homo sapiens (human)
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activityRetinal dehydrogenase 1Homo sapiens (human)
NAD bindingRetinal dehydrogenase 1Homo sapiens (human)
3-deoxyglucosone dehydrogenase activityRetinal dehydrogenase 1Homo sapiens (human)
benzaldehyde dehydrogenase (NAD+) activityRetinal dehydrogenase 1Homo sapiens (human)
aldehyde dehydrogenase (NAD+) activityAldehyde dehydrogenase, mitochondrialHomo sapiens (human)
aldehyde dehydrogenase [NAD(P)+] activityAldehyde dehydrogenase, mitochondrialHomo sapiens (human)
phenylacetaldehyde dehydrogenase activityAldehyde dehydrogenase, mitochondrialHomo sapiens (human)
electron transfer activityAldehyde dehydrogenase, mitochondrialHomo sapiens (human)
nitroglycerin reductase activityAldehyde dehydrogenase, mitochondrialHomo sapiens (human)
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activityAldehyde dehydrogenase, mitochondrialHomo sapiens (human)
NAD bindingAldehyde dehydrogenase, mitochondrialHomo sapiens (human)
carboxylesterase activityAldehyde dehydrogenase, mitochondrialHomo sapiens (human)
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activityAldehyde dehydrogenase X, mitochondrialHomo sapiens (human)
NAD bindingAldehyde dehydrogenase X, mitochondrialHomo sapiens (human)
aldehyde dehydrogenase (NAD+) activityAldehyde dehydrogenase X, mitochondrialHomo sapiens (human)
retinal dehydrogenase activityAldehyde dehydrogenase family 1 member A3Homo sapiens (human)
aldehyde dehydrogenase [NAD(P)+] activityAldehyde dehydrogenase family 1 member A3Homo sapiens (human)
protein homodimerization activityAldehyde dehydrogenase family 1 member A3Homo sapiens (human)
thyroid hormone bindingAldehyde dehydrogenase family 1 member A3Homo sapiens (human)
NAD+ bindingAldehyde dehydrogenase family 1 member A3Homo sapiens (human)
aldehyde dehydrogenase (NAD+) activityAldehyde dehydrogenase family 1 member A3Homo sapiens (human)
G protein activityGuanine nucleotide-binding protein GHomo sapiens (human)
adenylate cyclase activator activityGuanine nucleotide-binding protein GHomo sapiens (human)
endopeptidase activityDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
metalloendopeptidase activityDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
Notch bindingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
interleukin-6 receptor bindingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
integrin bindingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
protein bindingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
peptidase activityDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
metallopeptidase activityDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
SH3 domain bindingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
cytokine bindingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
PDZ domain bindingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
tumor necrosis factor bindingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
metal ion bindingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
metalloendopeptidase activity involved in amyloid precursor protein catabolic processDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingTAR DNA-binding protein 43Homo sapiens (human)
DNA bindingTAR DNA-binding protein 43Homo sapiens (human)
double-stranded DNA bindingTAR DNA-binding protein 43Homo sapiens (human)
RNA bindingTAR DNA-binding protein 43Homo sapiens (human)
mRNA 3'-UTR bindingTAR DNA-binding protein 43Homo sapiens (human)
protein bindingTAR DNA-binding protein 43Homo sapiens (human)
lipid bindingTAR DNA-binding protein 43Homo sapiens (human)
identical protein bindingTAR DNA-binding protein 43Homo sapiens (human)
pre-mRNA intronic bindingTAR DNA-binding protein 43Homo sapiens (human)
molecular condensate scaffold activityTAR DNA-binding protein 43Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (27)

Processvia Protein(s)Taxonomy
cytoplasmRetinal dehydrogenase 2Homo sapiens (human)
cytosolRetinal dehydrogenase 2Homo sapiens (human)
perinuclear region of cytoplasmRetinal dehydrogenase 2Homo sapiens (human)
cytoplasmRetinal dehydrogenase 1Homo sapiens (human)
cytosolRetinal dehydrogenase 1Homo sapiens (human)
axonRetinal dehydrogenase 1Homo sapiens (human)
synapseRetinal dehydrogenase 1Homo sapiens (human)
extracellular exosomeRetinal dehydrogenase 1Homo sapiens (human)
mitochondrionAldehyde dehydrogenase, mitochondrialHomo sapiens (human)
mitochondrial matrixAldehyde dehydrogenase, mitochondrialHomo sapiens (human)
extracellular exosomeAldehyde dehydrogenase, mitochondrialHomo sapiens (human)
nucleoplasmAldehyde dehydrogenase X, mitochondrialHomo sapiens (human)
mitochondrionAldehyde dehydrogenase X, mitochondrialHomo sapiens (human)
mitochondrial matrixAldehyde dehydrogenase X, mitochondrialHomo sapiens (human)
cytosolAldehyde dehydrogenase X, mitochondrialHomo sapiens (human)
cytoplasmAldehyde dehydrogenase family 1 member A3Homo sapiens (human)
cytosolAldehyde dehydrogenase family 1 member A3Homo sapiens (human)
extracellular exosomeAldehyde dehydrogenase family 1 member A3Homo sapiens (human)
plasma membraneGuanine nucleotide-binding protein GHomo sapiens (human)
cell-cell junctionDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
focal adhesionDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
ruffle membraneDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
Golgi membraneDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
cytoplasmDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
endoplasmic reticulum lumenDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
cytosolDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
plasma membraneDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
cell surfaceDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
actin cytoskeletonDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
membraneDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
apical plasma membraneDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
membrane raftDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
plasma membraneDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
intracellular non-membrane-bounded organelleTAR DNA-binding protein 43Homo sapiens (human)
nucleusTAR DNA-binding protein 43Homo sapiens (human)
nucleoplasmTAR DNA-binding protein 43Homo sapiens (human)
perichromatin fibrilsTAR DNA-binding protein 43Homo sapiens (human)
mitochondrionTAR DNA-binding protein 43Homo sapiens (human)
cytoplasmic stress granuleTAR DNA-binding protein 43Homo sapiens (human)
nuclear speckTAR DNA-binding protein 43Homo sapiens (human)
interchromatin granuleTAR DNA-binding protein 43Homo sapiens (human)
nucleoplasmTAR DNA-binding protein 43Homo sapiens (human)
chromatinTAR DNA-binding protein 43Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (25)

Assay IDTitleYearJournalArticle
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1199876Activation of recombinant human ALDH3A1 using benzaldehyde as substrate at 100 uM preincubated for 2 mins with NAD+ followed by substrate addition by UV-Vis spectrophotometric analysis2015Journal of medicinal chemistry, Feb-26, Volume: 58, Issue:4
Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.
AID1199866Inhibition of recombinant human ALDH1A2 using propionaldehyde as substrate preincubated for 2 mins with NAD+ followed by substrate addition by UV-Vis spectrophotometric analysis2015Journal of medicinal chemistry, Feb-26, Volume: 58, Issue:4
Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.
AID1199901Inhibition of recombinant human ALDH1A1 using propionaldehyde as substrate preincubated for 2 mins with NAD+ followed by substrate addition by UV-Vis spectrophotometric analysis2015Journal of medicinal chemistry, Feb-26, Volume: 58, Issue:4
Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.
AID1199870Inhibition of recombinant human ALDH2 using propionaldehyde as substrate preincubated for 2 mins with NAD+ followed by substrate addition by UV-Vis spectrophotometric analysis2015Journal of medicinal chemistry, Feb-26, Volume: 58, Issue:4
Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.
AID1199881Activation of recombinant human ALDH1B1 using propionaldehyde as substrate at 20 uM preincubated for 2 mins with NAD+ followed by substrate addition by UV-Vis spectrophotometric analysis2015Journal of medicinal chemistry, Feb-26, Volume: 58, Issue:4
Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.
AID1199886Inhibition of human ALDH1A1 G458N mutant using propionaldehyde as substrate at 100 uM preincubated for 2 mins with NAD+ followed by substrate addition by UV-Vis spectrophotometric analysis relative to control2015Journal of medicinal chemistry, Feb-26, Volume: 58, Issue:4
Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.
AID1199879Activation of recombinant human ALDH1A3 using propionaldehyde as substrate at 20 uM preincubated for 2 mins with NAD+ followed by substrate addition by UV-Vis spectrophotometric analysis2015Journal of medicinal chemistry, Feb-26, Volume: 58, Issue:4
Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.
AID1199868Inhibition of recombinant human ALDH1A3 using propionaldehyde as substrate preincubated for 2 mins with NAD+ followed by substrate addition by UV-Vis spectrophotometric analysis2015Journal of medicinal chemistry, Feb-26, Volume: 58, Issue:4
Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.
AID1199880Activation of recombinant human ALDH2 using propionaldehyde as substrate at 20 uM preincubated for 2 mins with NAD+ followed by substrate addition by UV-Vis spectrophotometric analysis2015Journal of medicinal chemistry, Feb-26, Volume: 58, Issue:4
Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.
AID1199872Inhibition of recombinant human ALDH1B1 using propionaldehyde as substrate preincubated for 2 mins with NAD+ followed by substrate addition by UV-Vis spectrophotometric analysis2015Journal of medicinal chemistry, Feb-26, Volume: 58, Issue:4
Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.
AID1199878Activation of recombinant human ALDH1A2 using propionaldehyde as substrate at 20 uM preincubated for 2 mins with NAD+ followed by substrate addition by UV-Vis spectrophotometric analysis2015Journal of medicinal chemistry, Feb-26, Volume: 58, Issue:4
Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.
AID1199882Activation of recombinant human ALDH3A1 using benzaldehyde as substrate at 20 uM preincubated for 2 mins with NAD+ followed by substrate addition by UV-Vis spectrophotometric analysis2015Journal of medicinal chemistry, Feb-26, Volume: 58, Issue:4
Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's4 (66.67)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.35

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.35 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.30 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.35)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
theophylline
[no description available]		2.1110dimethylxanthineadenosine receptor antagonist;
anti-asthmatic drug;
anti-inflammatory agent;
bronchodilator agent;
drug metabolite;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
fungal metabolite;
human blood serum metabolite;
immunomodulator;
muscle relaxant;
vasodilator agent
caffeine
[no description available]		2.1110purine alkaloid;
trimethylxanthine		adenosine A2A receptor antagonist;
adenosine receptor antagonist;
adjuvant;
central nervous system stimulant;
diuretic;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
environmental contaminant;
food additive;
fungal metabolite;
geroprotector;
human blood serum metabolite;
mouse metabolite;
mutagen;
plant metabolite;
psychotropic drug;
ryanodine receptor agonist;
xenobiotic
4-(diethylamino)benzaldehyde
4-(diethylamino)benzaldehyde : A member of the class of benzaldehydes carrying a diethylamino substituent at position 4.		2.1110aromatic amine;
benzaldehydes;
tertiary amino compound		EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Innate Inflammatory Response
[description not available]		02.0510
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.0510